Our community is in a relentless pursuit of therapies! 

Nutritional replacement therapies for CDG 

 

N-Acetylglucosamine (GlcNAc) is considered for the following CDG types:

About PGM3-CDG: is an inherited condition that primarily affects the immune system but can also involve other areas of the body. The pattern and severity of this disorder's signs and symptoms typically vary. 

 

How can you help our CDG community? Is easy! Share among your social media and other channels the information we make available within this section and website. This raises awareness, accelerates diagnosis, and secures better care and management for our CDG children and adults!

What is N-Acetylglucosamine (GlcNAc)?      

GlcNAc is a sugar necessary for the communication between the cells in our body. 

How can N-Acetylglucosamine (GlcNAc) help people living with PGM3-CDG? 

The PGM3 protein is responsible for making the active form of GlcNAc (UDP-GlcNAc). Defects in the PGM3 protein cause GlcNAc depletion. Thus, GlcNAc  supplementation restored its  levels inside the cells. A clinical trial (NCT02511041) to study the effect of GlcNAc in combination with uridine was done between 2015 and 2017. However, no results have been published yet.

 

Publications in CDG are constantly growing. We  have selected articles of special interest for you, see below. Not all are open access, thus if you wish to  access the full information, please contact us at https://worldcdg.org/contact

Keep in mind, you are not alone. Though Congenital Disorders of Glycosylation (CDG) are categorized as “rare” there is an amazing community at your fingertips working day and night to improve the lives of many people living with CDG and their family members. We want you to know everything that is available about therapies in lay language, but we suggest you enter into it at your own pace and comfort level.

We are here to help
Should you need more details please do get in touch with our Team

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For further learning about CDG, move ahead to our community tailored sections across https://worldcdg.org/  

 

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Authors

Vanessa Ferreira and Sandra Brasil (CDG & Allies FCT, NOVA University, World CDG Organization and Portuguese Association for CDG).  Ines Santos, Tiago Martins, Madalena Raposo from Sci and Volunteer Program Nova School of Science and Technology 2021. Ana Sofia Rodrigues (content management, CDG & Allies FCT, NOVA University, World CDG Organization and Portuguese Association for CDG).

Disclaimer

The Site cannot and does not contain medical or health advice. The information is provided for general informational and educational purposes only and is not a substitute for professional advice.

Accordingly, before taking any actions based upon such information, we encourage you to consult with the appropriate professionals. We do not provide any kind of medical or health advice. The use or reliance of any information contained on this site is solely at your own risk.

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CDG
Congenital Disorders of Glycosylation

Page modified at Monday, July 11, 2022 - 16:46