Magnesium

Sugars
- Mannose
- Fucose
- Galactose
- Sialic acid
- ManNAc
- Ace-ER
- Ribitol
- GlcNAc-PI
- GlcNAc
- Concerns
Ions
- Magnesium
- Iron
- Manganese
Other
Non-Nutritional

Our community is in a relentless pursuit of therapies!

Nutritional replacement therapies for CDG

Magnesium (Mg2+) is considered for the following CDG types:

MAGT1-CDG (more information about this specific CDG type HERE and HERE)

About MAGT1-CDG: patients with MAGT1-CDG have mild primary combined immune deficiency, persistent elevation of viral load in Epstein-Barr virus and increased incidence of B cell lymphomas.

How can you help our CDG community? Is easy! Share among your social media and other channels the information we make available within this section and website. This raises awareness, accelerates diagnosis, and secures better care and management for our CDG children and adults!

What is Magnesium?

Magnesium is a mineral that plays many crucial roles in your body, such as supporting muscle and nerve function and energy production.

How can Magnesium help people living with MAGT1-CDG?

The MAGT1 protein transports magnesium inside the cell. When it is not working properly, there is a general lack of magnesium, which affects glycosylation. Magnesium supplementation has shown encouraging results in cells and a patient has been reported to be on oral Mg2+ therapy. By giving external magnesium the defect in the protein which transports magnesium inside the cell (which is caused by a defect in glycosylation) can be bypassed. Unfortunately, no patient follow-up has yet been reported. Continue reading more about the supplementation with magnesium for the MAGT1-CDG at CDG Therapies: From Bench to Bedside.

Publications in CDG are constantly growing. We have selected articles of special interest for you, see below. Not all are open access, thus if you wish to access the full information, please contact us at https://worldcdg.org/contact

Keep in mind, you are not alone. Though Congenital Disorders of Glycosylation (CDG) are categorized as “rare” there is an amazing community at your fingertips working day and night to improve the lives of many people living with CDG and their family members. We want you to know everything that is available about therapies in lay language, but we suggest you enter into it at your own pace and comfort level.

We are here to help
Should you need more details please do get in touch with our Team

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For further learning about CDG, move ahead to our community tailored sections across https://worldcdg.org/

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Authors

Vanessa Ferreira and Sandra Brasil (CDG & Allies FCT, NOVA University, World CDG Organization and Portuguese Association for CDG). Ines Santos, Tiago Martins, Madalena Raposo from Sci and Volunteer Program Nova School of Science and Technology 2021. Ana Sofia Rodrigues (content management, CDG & Allies FCT, NOVA University, World CDG Organization and Portuguese Association for CDG).

Disclaimer

The Site cannot and does not contain medical or health advice. The information is provided for general informational and educational purposes only and is not a substitute for professional advice.

Accordingly, before taking any actions based upon such information, we encourage you to consult with the appropriate professionals. We do not provide any kind of medical or health advice. The use or reliance of any information contained on this site is solely at your own risk.

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